[kscarrol]

I was there in December, Union Square area, and never had any issues. Walked out for dinner, drinks and stopping at the Occidental Cigar Club several times. Stay away from the Tenderloin but as dradernh points out there are plenty safe things to do/see in and around the SF.

Edit: I would say it's no different than NYC or any other big city. Do you homework, know where to stay away from and always be aware of what's going on around you, but then being from NYC you will be aware of these things.