I have Plex running on a dedicated server using WHS2011. I do intend to replace the WHS box (which is almost 6 years old now) with a new server based on W10 but still using Plex (haven't looked at Emby but it's interesting).
In short, we have several clients that access Plex: Roku 3, Roku 4, Xbox One, W10 tablet (Surface Pro 4), and iPad. It just works and works well. As long as you have the hardware to support multiple streams at the resolution/bandwidth you want (eg. 720p or 1080p) it's an effective solution. The Roku 4 and Xbox One are connected via gigabit LAN which certainly helps.
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